In Capsule form

This Label for use with the exception of Canada and China. For Use in Clinical Trials Only.

Follow the written instructions provided by your Physician. For oral consumption.
Do not use later than 6 months after opening this container. ISQ950AN™ is currently being tested in humans but is not approved as a drug.
Keep out of sight and out of reach of children. Store in a dry place under 25°C.

Bottle: White HDPE Gerresheimer Article 45100 DUMA 100ml with pilferproof twist off dessicant cap and printed labelCapsules: Capsugel V-Caps Plus size 0 (orange or green color depending on country. Orange color used primarily for Covid 19 Clinical Trials)

Each capsule contains:

ISQ950AN™ Isoquercetin (250mg), Vitamin C (60mg), Niacin (5mg)

Lot Number: Shown on bottle | Expires: Date shown on bottle

You can view label translations now for capsules destined for Covid 19 trials. Covid 19 destined product, please click on icons for views.

TO ALL OUR CLINICAL TRIAL PARTNERS

We are available to help with fitting the label to your labelling machinery for the size of bottle used.
Placebo capsules also available.

In Soft Chew form

DO NOT USE IF YOU ARE ALLERGIC TO SOY BASED PRODUCTS

Use Globally outside of Canada and China
For Use in Clinical Trials Only.

Follow the written instructions provided by your Physician. For oral consumption. Do not use later than 1 month after opening this container. ISQ950AN™ is currently being tested in humans but is not approved as a drug. Keep out of sight and out of reach of children. Store in a dry place under 25°C.

IMPORTANT EXTRA WARNING: DO NOT USE IF YOU ARE ALLERGIC TO SOY PRODUCTS AS SOY LETHICIN IS USED IN A VERY SMALL AMOUNT AS A BINDING AGENT IN THE MANUFACTURE OF THE SOFT CHEWS (chewable tablets)

30 Soft Chews
(chewable tablets)

Package:
Resealable Aluminum Pouch with Paper Label.Soft Chews:
Approximately 5.4 grams each soft chews individually wrapped in aluminum foil.Light Yellow color used primarily for Covid 19 Clinical Trials.

Each Soft Chew contains:

ISQ950AN™ Isoquercetin (average 500mg), Vitamin C ( average 120mg), Niacin (average 10mg)

Lot Number: Shown on pouch package | Expires: Date shown on pouch package

TYPICAL LABEL SOFT CHEWS
(chewable tablets)

Powder

IN BULK POWDER FORM IN WHITE HDPE TUB WITH ADDED HIGHER VITAMIN C, NIACIN AND ADDED FOLIC ACID.

This product contains no excipients and is pure for use mixed with water or other consumeable liquid in a feeding tube or for patients who cannot swallow capsules or use chewable tablets due to deteriorated condition in the oral consumption capability of the patient

Per 100 grams of powder:

ISQ950AN™ Isoquercetin 47.4 grams, Vitamin C 47.4 grams, Niacin 4.7 grams, Folic Acid 0.5 grams

To get a 1000mg dose of isoquercetin use approximately 2.2 grams (approximately 45 doses per container).To get 2000mg of isoquercetin use approximately 4.4 grams (approximately 23 doses per container).

Lot Number: Shown on pouch package | Expires: Date shown on pouch package

Studies

high-priority indication:
COVID-19

Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, Zhang H, Luo H, Zhu L, Jiang P, Chen L, Shen Y, Luo M, Zuo G, Hu J, Duan D, Nie Y, Shi X, Wang W, Han Y, Li T, Liu Y, Ding M, Deng H, Xu X. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 2004 Oct;78(20):11334-9.

Lili Chen et al. 2006.
Binding interaction of quercetin-3-b-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features. Bioorganic & Medicinal Chemistry 14 (2006) 8295–83.

Khaerunnisa, S.; Kurniawan, H.; Awaluddin, R.; Suhartati, S.; Soetjipto, S. Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. Preprints 2020, 2020030226 (doi: 0.20944/preprints202003.0226.v1).

Nguyen et al 2012.
Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. Biotechnol Lett 2012;34:831–8.